National Academy of Sciences of Belarus

KHRIPACH Vladimir Aleksandrovich

KHRIPACH Vladimir Aleksandrovich

Vladimir Aleksandrovich Khripach (b. 02.10.1949, Minsk), chemist. Academician of the National Academy of Sciences of Belarus (2014; corresponding member since 2000), Doctor of Chemical Sciences (1990), Professor (1997).

Scientific works in the field of bioorganic chemistry. Conducted research on the chemistry of steroid hormones and related bioregulators. Revealed a class of immunomodulators as the basis of new drugs to stimulate immunity in humans and farm animals. He created a nitrileox methodology for obtaining key intermediates of steroids and other bioactive compounds, discovered new regio- and stereoselective reactions. Research in this field related to the chemistry of 2-isoxazolines opened up the possibility of using the latter in the practice of organic synthesis and allowed us to create a domestic analogue of the pesticide "tachigaren" based on 3-hydroxy-5-methylisoxazole. On the basis of one of the phytohormones, the drug Epin was developed, which was field tested and allowed for use in agriculture (the drug is used in Russia, Belarus and Ukraine to increase crop yields and improve product quality). Developed approaches to the synthesis of other classes of natural steroids - ecdysones (insect hormones), vitamins D, sea sterols, biologically active ingredients of medicinal plants.

Author of more than 500 scientific papers, incl. 6 monographs, 60 copyright certificates and patents.

State Prize of the Republic of Belarus in 1996 for the synthesis, research and use of brassinosteroids - a new class of plant hormones.

Major papers:

  1. Брассиностероиды. Мн.: Наука и техника, 1993 (совм. с В.Н. Жабинским, Ф.А. Лахвичем).
  2. Brassinosteroids: A New Class of Plant Hormones. San Diego: Academic Press, 1999 (with V.N. Zhabinskii, Ae. de Groot).
  3. Twenty Years of Brassinosteroids: Steroidal Plant Hormones Warrant Better Crops for the XXI Century (with V. Zhabinskii, Ae. de Groot) // Annals of Botany. 2000. Vol.86.
  4. New practical aspects of brassinosteroids and results of their ten-year agricultural use in Russia and Belarus (with V.N. Zhabinskii, N.B. Khripach) // Brassinosteroids. Bioactivity and Crop Productivity. Еds. S. Hayat, A. Ahmad. Dordrecht: Kluwer Academic Publisher, 2003. P.189-230.
  5. Brassinosteroids: a new role of steroids as bio-signaling molecules (with V. Zhabinskii, R. Karnachuck) // Chemical Probes in Biology. Ed. M.P.Schneider. Dordrecht: Kluwer Academic Publisher, 2003. P.153-165.
  6. 2,3-Epoxybrassinosteroids are intermediates in the biosynthesis of castasterone in seedlings of Secale cereale (in coauth.) // Phytochemistry. 2005. V. 66. No.1.
  7. Оксистерины: генезис и основные функции (совм. с А.В. Антончиком, В.Н. Жабинским) // Биоорганическая химия. 2007. Т.33, №3.
  8. Synthetic aspects of brassinosteroids (with V. N. Zhabinskii, Y. V. Ermolovich) // Studies in Natural Products Chemistry. Ed. Atta-ur-Rahman. Amsterdam: Elsevier, 2015. V. 44. P. 309-352.
  9. Steroid plant hormones: effects outside plant kingdom (with V. N. Zhabinskii, N. Khripach) // Steroids. 2015. V. 97. P. 87-97.
  10. A new ELISA for quantification of brassinosteroids in plants (in coauth.) // Steroids. 2015. V. 97. P. 78-86.