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Corresponding Members

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Usanov S.A.

Corresponding Member Sergey A. USANOV

Usanov, Sergey Alexandrovich (Born: 14.05.1948)

Qualifications
Doctor of the Chemical Sciences (since 1990), Professor (2003).
Corresponding Member of the National Academy of Sciences of Belarus. Elected in 2004 on specialty Bioorganic Chemistry.

Membership of other Academies, Scientific Societies and Councils
Member of the Scientific Council of the Institute of Bioorganic Chemistry National Academy of Sciences of Belarus,
Member of the Scientific Doctorate Degree Council at the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus

Training
1993-1995 - Professor of the National Institute of Environmental Health Sciences (NIEHS, Research Triangle Park, North Carolina, USA).
1997-2001 - Professor of the Department of Biochemistry, University of Texas Southwestern Medical Center (Dallas, Texas, USA).
2003-2004 - Professor of the Medical Center at Osaka University (Osaka, Japan).

Current Position
The Academician-Secretary of the Department of Chemistry and Earth Sciences.
66 Praspekt Nezalezhnastsi, Minsk BY-220072, Republic of Belarus
Tel.: +375 (17) 284-03-71. Fax: +375 (17) 284-03-71. E-mail: chemistry@presidium.bas-net.by

The Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Director
5 Academician V.F.Kuprevich Street, Build.2, Minsk BY-220141, Republic of Belarus
Tel.: +375 (17) 263-72-74. Fax: +375 (17) 263- 72-74. E-mail: usanov@iboch.bas-net.by

Research areas
Research interests in bioorganic chemistry, biotechnology and molecular biology. Structure and function of the cytochrome P450 dependent monooxygenase systems involved in biosynthesis of physiologically active bioregulators and xenobiotics metabolism. Elucidation of the molecular mechanisms of some inherited diseases connected with disturbances of steroid hormone biosynthesis and hormonal regulation.

Main Publications
1. Guryev O.L., Gilep A.A., Usanov S.A., Estabrook R.W. Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A. Relevance of heme transfer reactions // Biochemistry. 2001, Vol.40, P.5018-5031.
2. Gilep A.A., Guryev O.L., Usanov S.A., Estabrook R.W. Expression, purification and physical properties of recombinant flavocytochrome fusion proteins containing rat cytochrome b5 linked to NADPH-cytochrome P450 reductase by different membrane-binding segments // Arch. Biochem. Biophys. 2001, Vol.390, No.2, P.222-234.
3. Usanov S.A., Gilep A.A., Lepesheva G.I., Strushkevich N.V., Azeva T.N., Graham S., Peterson J.A., Estabrook R.W. Probing the interaction of cytochrome P450scc (CYP11A1) with adrenodoxin: evaluating site-directed mutations by molecular modeling // Biochemistry. 2002, Vol.41, No.26, P.8310-20.
4. Guryev О., Carvalhot R., Usanov S., Gilep А. and Estabrook R. W. А new pathway for the metabolism of vitamin Dз: Uniqie hydroxylated metabolites formed during catalysis with cytochrome P450scc (СУРIIА1) // PNAS USA. 2003, Vol.100, No.25, P.14754-14759.
5. Min L., Strushkevich N.V., Harnastai I.N., Iwamoto H., Gilep A.A., Takemori H., Usanov S.A., Nonaka Y., Hori H., Vinson G.P., Okamoto M. Molecular identification of adrenal inner zone antigen as a heme-binding protein // FEBS J. 2005, Vol.272, No.22, P.5832-43.
6. Cherviakovsky E.M., Bolibrukh D.A., Baranovsky A.V., Vlasova T.M., Kurchenko V.P., Gilep A.A., Usanov S.A. Oxidative modification of quercetin by hemeproteins // Biochem. Biophys. Res. Commun. 2006, Vol.342, No.2, P.459-64.
7. Duarte M.P., Palma B.B., Gilep A.A., Laires A., Oliveira J.S., Usanov S.A., Rueff J., Kranendonk M. The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450-mediated biotransformation // Mutagenesis. 2007, Vol.22, No.1, P.75-81.
8. Harnastai I.N., Gilep A.A., Usanov S.A. The development of an efficient system for heterologous expression of cytochrome P450s in Escherichia coli using hemA gene co-expression // Protein Expr. Purif. 2007, Vol.46, No.1, P.47-55.
9. Pechurskaya, T.A., Harnastai I.N., Grabovec I.P., Gilep A.A., Usanov S.A. Adrenodoxin supports reactions catalyzed by microsomal steroidogenic cytochrome P450s // Biochem. Biophys. Res. Commun. 2007, Vol.353, No.3, P.598-604.

Literature
1. Sergei Alexandrovich Usanov (On the occasion of 60th birthday) (In Russian, Win1251)

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