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Изв. Нац. академии наук Беларуси. Сер. мед. наук, 2005, No.4

Главная страница / Издания академии / Научные журналы

Изв. Нац. академии наук Беларуси. Сер. мед. наук, 2005, No.4

Известия Национальной академии наук Беларуси
СЕРИЯ МЕДИЦИНСКИХ НАУК

Издатель Беларуская навука, Минск, Республика Беларусь

Номер 4, 2005

Предыдущий Журнал Следующий

СОДЕРЖАНИЕ


КЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА

Beloenko E. D., Ilyasevich I. A., Rutkevich S. A., Yusefovich A. I., Sokolovsky O. A.
Physiological aspects of the functional changes in pelvic girdle and thigh muscles at biomechanical failures of hip joint. pp. 5--10

Summary: The Electrophysiological investigation of the functional state of pelvic girdle and thigh muscles at failure of hip joint was carried out (28 teenagers with hip joint dysplasia). Electrophysiological criteria of the different-degree neuromuscular dysfunction with the predicted meaning have been formulated. The physical training with the use of the biological feedback method allows increasing the efficiency of post-surgical rehabilitation.

Kozlov I. D., Grakovich A. A., Apanasevich V. V.
Analysis of the pulse wave velocity for estimating the risk of the ischemic heart disease. pp. 11--15

Summary: The aim of our study was to evaluate the influence of the indicators on the speed of pulse wave (SPW) propagation upon the frequency, absolute and relative risk for the development of myocardial infarction and death from chronic ischemic heart disease. The obtained data enable one to consider the increase of the pulse wave velocity along the aorta as a new significant factor for the development of myocardial infarction. This is an intermediate link in the succession of the development of cardiovascular continuum, which represents a transition from the availability of atherosclerosis risk factors, reflecting, as a matter of fact, the statistical patterns typical of the population as a whole, to the initial manifestations of the individual reaction of an organism to the effect of these factors. Our results prove a hypothesis that the detection of the changes in the characteristics of the main and large arteries by the non-specific methods of investigation such as the measurement of the velocity and time of pulse wave propagation allows us to significantly increase the accuracy of the quantitative estimation of the individual risk for the development of cardiovascular diseases in asymptomatic patients which at present is based only on the available risk factors.

Alexeev S. A., Semenenya I. N., Adzerikho I. E., Gain Yu. M., Sokolov Yu. A.
Use of the modern immunocor-rectors in the complex treatment of peritonitis. pp. 16--19

Summary: Experimental researches carried on 72 white rats have revealed that the application of antibiotics and immunomodula-tors in combination reduces the manifestation of systemic inflammatory response and increases the activities of nonspecific resistance mechanisms. The most considerable results were found in the group of the laboratory animals which were treated by the combinations ceftriaxon + imunofan + cycloferon and ceftriaxon + polyoxydonium.

Antipenko A. A., Pashkevich S. G., Kandybo T. S., Iliasevich I. A., Kulchitsky V. A.
Disturbance of the central control of circadian rhythms after experimental destruction of subcoeruleus neurons. pp. 20--23

Summary: Two or three weeks after bilateral destruction by kainic acid of 2 mg/ml (in 25 nl) of neuronal populations of the rat ventral locus coeruleus it was found that the circadian control of the arterial pressure and nociceptive response (fail-flick reflex) changed. Analysis of the obtained experimental facts and literature data revealed the key role of neuronal populations of basal locus coeruleus in the functioning of the central control system of circadian rhythms.

Kuzmitsky B. B., Golubeva M. B., Konoplya N. A., Lyubin G. S., Milevich T. I.
Extracts of Pleurotus ostreatus (Fr.) Kumm as B-lymphocytes polyclonal activators. pp. 24--28

Summary: The ability of Pleurotus ostreatus (Fr.) Kumm to stimulate the immune system was shown to be an important constituent of its bioactivity range. The immunopositive effect of the mushroom depends on the bioavailability of its active ingredients and, in turn, on the physical and chemical capacities of mushroom-derived extracts. The stimulating influence of extracts I and II, which are different in their solubilities in the sodium chloride isotonic solution, is most likely carried out through their preferential effects on the humoral immunity (T-independent immunoac-tivation) in CBA and C57BL/6 mice immunized with sheep red blood cells. The fact that the studied extracts are able to restore completely (extract I) or to some extent (extract II) the quantity of antibody-forming cells in the animals irradiated once at a dose of 2.0 Gr, is of particular interest.

Tahanovich A. D., Lobanova E. M.
Specific features of the hydrogen peroxide metabolism in rat alveolar macrophages during exposure to the lack of oxygen and the high temperature. pp. 29--33

Summary: The influence of a combination of heat and low maintenance of O2 in the incubation environment on a oxidants/antioxidants balance of alveolar macrophages (AM) was studied (experience in vitro). These cells are known to be one of the basic producers of free oxygen radicals in the lung. The sharp increase of the level of H2O2 produced by AM in these conditions was revealed. The reason of it appeared to be not only the increase in the H2O2 formation, but also the decrease of its decomposition (according to the suppressed activity of catalase and glutathionperoxidase). It was established that the expressed accumulation of lipids peroxidation products in cells on the a background of the activated pentose phosphate pathway and nitrogen oxide (NO) formation.

Tropnikova G. K.
Effect of antiorthostatic hypokinesia on the activity of brain and spinal serotoninergic structures in rats. pp. 34--37

Summary: In experiments on conscious adult white rats (230--250 g) it is found that ANOH applied for 2 h (head--down body position at an angle of 30°) in comparison with control (horisontal position) leds to a significant decrease in the serotonin (5-HT) level in the striatum and hippocampus and its accumulation in the midbrain and ventrolateral medulla, without changes in 5-hydroxyindoleacetic acid (5-HIAA) in them. No significant changes in 5-HT and 5-HIAA in the parietal cortex, cerebellum, and caudal raphe nuclei, thoracic and lumbosacral spinal segments are observed in this period.

Kizyukevich L. S.
Renal dysfunction during experimental cholestasis. pp. 38--41

Summary: In the treated rats, the serum urea concentration incrensed for 72 of cholestasis. Such animals displayed polyuria, higher daily urea excretion, lower urinary sodium concentration (as low as 58.3% from its control values), lower minimal urea clearance (in the absence of the renal pathology it cannot be lower than 75%). Thus, the results have shown that 3 days of cholestasis are associated with the development of renal insufficiency. The novelty of these results is the establishment of possible renal insufficiency in the prerenal form during the acute phase of experimental cholestasis.

Generalov I. I.
Interaction of human catalytic IgG with ion-exchange matrices. pp. 42--48

Summary: The chromatographic behavior of human polyclonal IgG with the catalytic (abzyme) activity fractionated at various ion-exchange resins was studied. It was determined that the IgG preparations revealed the marked heterogeneity during chromatography. Particular IgG molecules bound to charged resins were eluted by high ionic strength solutions, while the major part of immunoglobulins did not interact with the matrices being eluted in the free volume. For some of the IgG preparations the ion-exchange chromatography made possible to raise substantially the catalytic activity of abzyme fractions.

Sugak N. K., Khulup G. Y., Shved I. A.
Comparative description of the apoptosis of the neurons of neocortex fields 4 and 10 in fetuses and newborns suffered from intraventricular hemorrhages. pp. 49--54

Summary: The result of investigation is the revelation of the morphology and intensity of neuronal apoptosis of neocortex fields 4 and 10 in fetuses (n = 12) which died in labor and in newborns (n = 38) with the gestational age of 22--36 weeks suffered from intraventricular hemorrhages of grade 1--3. Morphological, TUNEL. morphometrical and statistical methods have been used. Morphological criteria of apoptosis of neurons are specified. The dependences between the activity of the neuronal apoptosis of brain neocortex and the grade of intraventricular hemorrhages, newborns life time are revealed. It is established that the neuronal apoptosis of neocortex fields 4 and 10 of premature newborns plays a significant role in the development of a morphological substratum of psychoneurological symptoms in intraventricular hemorrhages (in particular, intellectual and movement disorders).

Litvinova T. M., Ulashchik V. S., Istomin Yu. P., Zhavrid E. A.
Experimental evaluation of antitumor activity of some cytostatics and laser hemotherapy. pp. 55--59

Summary: In experiments on animals, laser hemotherapy was found to enhance the antitumor activity of cisplatin and vinorelbine which is manifested by reduction in the growth of Ca-45 and to produce no effect on the cytostatic effect of etoposide and the three drugs administered concurrently. Laser hemotherapy does not alter the effect of etoposide, cisplatin and combination of these drugs with vinorelbine on RL-67 carcinoma metastasizing, decreasing the cytostatic effect of the latter.

Fomina E. G., Vladyko A. S., Fomin I. K.
Reverse transcription of retroviral genome: specific features of replicative minus-strand DNA transfer. pp. 60--65

Summary: The translocation of minus-strand DNA during reverse transcription occurs with the participation of short repeats or R regions that ensure the complementarity between the ends of viral genome. This work studies the range of the factors that, for exception of homology, can be involved in the minus-strand DNA transfer. For this aim the retroviral vectors with the additional 3' R regions inside of viral genome are used. The results of these studies showed that the dominant site for translocation was the R region in the surroundings of the U3 sequences of viral LTR, whereas the place of the R region, the presence of poly-A sequences on 3' end of viral RNA and the direction of homology finding were riot important for strand transfer. Thus, replicative minus-strand DNA transfer depends not only on the presence of homology on the ends of viral genome, but also include the early unknown mechanism involving viral sequences in the surroundings of the R region.

Gomon E. S., Sidorenko V. N.
Psychovegetative assessment of the birth progression. pp. 66--72

Summary: A complex clinic-instrumental and psychodiagnostic study of 116 women at the age of 18--30 was conducted. For the dependence of the influence of psychovegetative factors on the birth progression, namely, a delivery method, birth prolongation according to periods, use of analgesics in labor to be revealed, the consecutive consecutive correlative analysis (with the calculation of Peerson's correlation coefficient) of the data of psycho-diagnostic methods, parameters of cardiointervalography, peripheral and pelvic hemodynamics was made. Only reliable correlative relationships were taken into consideration in the study. The analysis made allowed one to establish the most significant regularities which may be used to predict a delivery method and a use of necessary analgesics in labor.

Voitovich A. M., Trusova V. D., Ogurtsova S. E., Krupnova E. V., Afonin V. Yu.
Micronuclei in the intestinal epithelium cells of C57BL/6J mice after exposure to different mutagens under the conditions of preliminary b-naph-thoflavone treatment. pp. 73--76

Summary: Preliminary intraperitoneal administration of b-naphthoflavone did not increase the number of glandular epithelium cells with micronu-clei in duodenum after exposure to 7.12 dimethylbenz(a)anthracene, cyclophosphamide and mitomicin C. Metabolic activation has resulted in an increase in the number of cells with micronuclei in small intestine and rectum after exposure to mitomycine C.

Antonovich A. N., Komissarova S. M., Slobozhanina E. I.
State of the glutathione system in the erythrocytes of patients with ischemic heart disease. pp. 77--81

Summary: The comparative investigation of the cytoplasmic glutathione S-transferase (GST) activity, contents of reduced glutathione (GSH) and its oxidized form (GSSG) in the erythrocytes of patients with ischemic heart disease (IHD) with a depressed left ventricular ejection fraction and with a kept left ventricular ejection fraction and healthy donors was carried out. It was shown that the mean level of the concentrations of GSH and GSSG in the erythrocytes of healthy donors was not diffrent from such in the erythrocytes of patients with IHD of the both groups. The activity of glutathione S-transferase in the erythrocytes of patients with IHD was much higher than in the erythrocytes of healthy donors. In erythrocytes of patients with IHD with a kept left ventricular ejection fraction the increasing of the activity of glutathione S-transferase was approximately 40%, of patients with a depressed left ventricular ejection fraction -- 70% in comparison with the erythrocytes of practically healtliy donors. So, our results confirmed that in the erythrocytes of patients with IHD the activity of the basic detoxification enzyme --glutathione S-transferase was increased and the level of the activity of GST depended on the degree of manifestation of IHD.

Zhdanov A. A.
Protective efficacy of acctylsalicylic acid in myocardial ischemia/reperfusion injury. pp. 82--84

Summary: Acetylsalicylic acid (aspirin) is known to be a powerful means for suppressing the synthesis of thromboxane. To assess the cardioprotective properties of the medication under the myocardial ischemia-reperfusion conditions, aspirin was administered intragastrically 1hr prior to the ischemia/reperfusion injury simulation. It has been proved that aspirin, when given in doses of 10--100 mg/kg, fails to exert any observed beneficial protective effects on both the mortality and the extent of myocardial injury following ischemia and reperfusion in rats.

Valuyevich V. V.
Radioiodine therapy of Graves' disease. pp. 85--92

Summary: The purpose of research was to estimate of the influence of radioiodine therapy (RIT) on the clinical and hormonal status of patients with Graves' disease (GD). 21 patients, aged 48 (35; 58), were examined. 20 persons initially received within 14 months (9; 30) antithyroid medication, which cancellation was made, as a rule, 2 day prior to RIT. 7 elderly and multimorbide patients continued to accept antithyroid drugs within several months after RIT. In 5 patients with autoimmune ophthalmopathy glucocorticoid treatment was carried out (0.5 mg/kg of body weight daily with gradual decrease of a dose) which began in day of reception of 131I and proceeded after discharging from a hospital within 4--6 weeks in outpatient conditions. Activities of 378--1489 MBq radioiodine were calculated by means of Marinelli' formula. Ablative dosage concept with a target dose 300 Gy (n = 19) and functional-optimized concept in patients with low risk of relapse 200Gy (n = 2) were used. An estimation of results of RIT was evaluated in 4 months (4; 5). The successful result (euthyrodism and hypothyroidism) was observed in 76% of cases, thus the volume of a thyroid gland has decreased for 52%. Frequency of hypothyroidism was 67%. It was concluded that hypothyroidism is a purpose of RIT for GD.

Sidorovich R. R.
Surgery for brachial plexus traumatic injuries by the autoneuroplasty technique. pp. 93--101

Summary: Based on the outcomes of interfascicular autoneuroplasty in 11 patients, a high enough efficiency of this technique was shown in treating for traumatic injuries of Brachial Plexus resulted in an extensive open trauma zone. Functionally significant good outcomes were obtained in 72.7% of the patients. The key indicator was diastasis more than 3 cm long between the proximal and distal extremes of the impaired Brachial Plexus structure. A correlation was found between effective autoneuroplasty and the size of diastasis between the proximal and distal extremes of and the level of damage that Brachial Plexus structures have sustained. Performing surgery with diastasis more than 7 cm long led to somewhat worse outcomes. Autoneuroplasty of trunks was less effective than that of proximal sections of Brachial Plexus nerves. Surgical interventions were carried out with due regard to anatomic and topographic features of Brachial Plexus, using microsurgical equipment, appropriate magnification, selecting optimal donor nerves, determining the length and number of required segments, differentiated matching the fascicles, groups of fascicles as well as making sure proper revasculization of the autotransplant.

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ОБЗОРЫ

Semenenya I. N.
Thinking and diseases. pp. 102--105

Summary: The article discusses the importance of the thinking activity in the man's life and the conditions for Keeping health.

Sidorenko G. I.
Urgent problems in arterial hypertension pathophysiology. pp. 106--109

Summary: Disputable problems in arterial hypertension diagnostics have been described. They relate to the notions regarding the optimal and normal arterial pressure level. N. S. Korotkov's manometric method urgent offered a hundred years ago is convenient for a certain self-control but it does not provide accurate assessment for target organs. Target organs have been characterized as viewed from the positions of blood autoregulation and circulation. Preconditioning adaptation mechanism regarding coronary and cerebral blood circulation has been also described.

Tret'yak S. I., Romanovich A. V., Khryshchanovich V. Ya.
Parathyroid transplantation: present state and perspectives. pp. 110--112

Summary: The article presents the modern views on the parathyroid transplantation in management of hypoparathyroidism. Indications and contraindications for transplantation, methods of transplantation, problems of transplant degrafting and immunosuppressive therapy were reviewed.

Pashuk V. P., Pashuk M. V.
Methodological and organizational approaches for detection and control of associative polyetiologic diseases. Historiography. Perspectives in solving the problem. pp. 113--123

Summary: The extensive materials of the research experience and available literature on mixt disease are stated, which is accepted as associative polyetiologic disease -- APD or just polyetiologic disease -- PD. It's determined that they-mixures appear naturally and are formed in epidemic biosystems of interspecific nature parasite -- host and constitute the complicated health problem with a big social meaning. Such poly processes are developing in clinicohumoral and organosystem-defined tnvironment of an affected person, disturbing multiply regulative functions of an organism, which result in changes of the immunological and general homeostasis. Associatively APD include multiple mixing of pathogens (infectious, invasive and others, including somatic pathology of different categories). Poly processes proceed clinically polymorphous, often atypically, rarely sub clinically or seriously with complications, and in isolated cases with lethal outcome. It is suggested the methodical completed classification of the control methods and preventive measures related to the emerging polypro-cesses with participation of the doctors-specialists of different activity profiles and the organization of the available scientific and practical center for assistance to clinical institutions upon request (can be payable basis).

Предыдущий Журнал Следующий

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Разработана и поддерживается Николаем Н. Костюковичем. Последнее обновление: 20 января 2006 г.
Создана при участии Игнатия И. Корсака
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Копирайт © 2005 Издательский дом "Беларуская навука"