Anatoly Ivanovich Zinchenko (b. 28.11.1946, mining village Shcheglovka, Donetsk region, Ukraine) - a scientist in the field of microbiology and biotechnology. Corresponding Member of the National Academy of Sciences of Belarus (2000), Doctor of Biological Sciences (1993), Professor (2006).
Scientific works in the field of microbial biotechnology. Performed research related to the targeted transformation of nucleic acids and their components by enzymes of microorganisms. He selected strains - producers of many enzymes of nucleic metabolism and studied the laws of biosynthesis and the physicochemical properties of these enzymes, the course of catalyzed reactions and the substrate specificity of enzymes in relation to natural and modified nucleotides, nucleosides and nitrogenous bases. The obtained data on the relationship of the structure of substrate molecules with enzymatic activity became the basis for predicting the ability of enzymes of microorganisms to catalyze reactions in a number of natural components of nucleic acids and their modified analogues and assess the prospects for biotechnological production of practically important compounds of nucleic nature. The complex transformation of DNA and RNA into a number of valuable compounds has been carried out. Bacterial nucleoside phosphotransferase gene was isolated and its expression was demonstrated in a heterologous system, genetically engineered strains were designed - superproducers of nucleoside phosphotransferase, nucleoside phosphorylase and lysyl-tRNA synthetase - enzymes necessary for the production of medicinal substances. Developed jointly with the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus and introduced into production original chemical-enzymatic technologies for the production of medicinal substances of highly effective domestic anticancer drugs "Leucladin" (2003) and "Fludarabel" (2006).
Author of more than 250 scientific works, 30 copyright certificates for inventions and patents.
State Prize of the Republic of Belarus in 2004 in the field of science and technology.