National Academy of Sciences of Belarus

MAZHUL Vladimir Mikhailovich

Vladimir Mikhailovich Mazhul (24.12.1939, Odessa – 29.08.2008), a scientist in the field of biophysics, proteomics. Corresponding Member of the National Academy of Sciences of Belarus (2004), Doctor of Biological Sciences (1986), Professor (1991).

Works in the field of molecular and membrane biophysics, protein photonics, proteomics. Established a new biophysical mechanism for regulating the activity of a proteome in normal and pathological conditions, implemented through transformations of the structural-dynamic state of proteins against the background of the constancy of their composition. He showed the importance of the role of the intramolecular dynamics of the protein globule in the implementation and regulation of the functional activity of proteins. He proposed a fluctuation model of enzyme-substrate interactions. He formulated and experimentally substantiated the concept of the possibility of the existence of a protein in a variety of partially folded states that differ in conformation, intramolecular dynamics, and functional activity. He developed a method for selectively monitoring the millisecond intramolecular dynamics of membrane proteins in living cells, based on recording the kinetic parameters of tryptophan phosphorescence at room temperature. Created instrumentation phosphorescent method.

Author of over 300 scientific papers, incl. monographs, 12 inventions.

State Prize of the Republic of Belarus in the field of science and technology in 1992.

Major papers:

  1. Межклеточные контакты. Мн.: Наука и техника, 1977 (совм. с С.В.Коневым).
  2. Внутримолекулярная динамика и функциональная активность белков (совм. с Е.М.Зайцевой, Д.Г.Щербиным) // Биофизика, 2000. Т.45, вып.6. С. 965-989.
  3. Monitoring of Actin Unfolding by Room Temperature Tryptophan Phosphorescence (in coauthorship) // Biochemistry, 2003. Vol.42. P. 13551-13557.
  4. Развитие исследований в области протеомики в Республике Беларусь: фундаментальные и прикладные аспекты // Наука и инновации, 2005. №7(29). С. 42-51.